A large case-control study on vaccination as risk factor for multiple sclerosis.
Identifieur interne : 000026 ( Main/Exploration ); précédent : 000025; suivant : 000027A large case-control study on vaccination as risk factor for multiple sclerosis.
Auteurs : Alexander Hapfelmeier [Allemagne] ; Christiane Gasperi [Allemagne] ; Ewan Donnachie [Allemagne] ; Bernhard Hemmer [Allemagne]Source :
- Neurology [ 1526-632X ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Facteurs de risque (MeSH), Facteurs temps (MeSH), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Maladie de Crohn (induit chimiquement), Maladie de Crohn (épidémiologie), Mâle (MeSH), Psoriasis (induit chimiquement), Psoriasis (épidémiologie), Sclérose en plaques (induit chimiquement), Sclérose en plaques (épidémiologie), Vaccination (effets indésirables), Études cas-témoins (MeSH).
- MESH :
- effets indésirables : Vaccination.
- induit chimiquement : Maladie de Crohn, Psoriasis, Sclérose en plaques.
- épidémiologie : Allemagne, Maladie de Crohn, Psoriasis, Sclérose en plaques.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Études cas-témoins.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adult (MeSH), Case-Control Studies (MeSH), Crohn Disease (chemically induced), Crohn Disease (epidemiology), Female (MeSH), Germany (epidemiology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Multiple Sclerosis (chemically induced), Multiple Sclerosis (epidemiology), Psoriasis (chemically induced), Psoriasis (epidemiology), Risk Factors (MeSH), Time Factors (MeSH), Vaccination (adverse effects), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Germany.
- adverse effects : Vaccination.
- chemically induced : Crohn Disease, Multiple Sclerosis, Psoriasis.
- epidemiology : Crohn Disease, Multiple Sclerosis, Psoriasis.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors, Time Factors, Young Adult.
Abstract
OBJECTIVE
To investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study.
METHODS
Using the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005-2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or psoriasis (n = 112,292) and participants with no history of these autoimmune diseases (n = 79,185) served as controls.
RESULTS
The odds of MS were lower in participants with a recorded vaccination (odds ratio [OR] 0.870,
CONCLUSIONS
Results of the present study do not reveal vaccination to be a risk factor for MS. On the contrary, they consistently suggest that vaccination is associated with a lower likelihood of being diagnosed with MS within the next 5 years. Whether this is a protective effect needs to be addressed by future studies.
DOI: 10.1212/WNL.0000000000008012
PubMed: 31363057
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31363057</idno><idno type="pmid">31363057</idno><idno type="doi">10.1212/WNL.0000000000008012</idno><idno type="wicri:Area/Main/Corpus">000011</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000011</idno><idno type="wicri:Area/Main/Curation">000011</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000011</idno><idno type="wicri:Area/Main/Exploration">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A large case-control study on vaccination as risk factor for multiple sclerosis.</title><author><name sortKey="Hapfelmeier, Alexander" sort="Hapfelmeier, Alexander" uniqKey="Hapfelmeier A" first="Alexander" last="Hapfelmeier">Alexander Hapfelmeier</name><affiliation wicri:level="3"><nlm:affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Gasperi, Christiane" sort="Gasperi, Christiane" uniqKey="Gasperi C" first="Christiane" last="Gasperi">Christiane Gasperi</name><affiliation wicri:level="3"><nlm:affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Donnachie, Ewan" sort="Donnachie, Ewan" uniqKey="Donnachie E" first="Ewan" last="Donnachie">Ewan Donnachie</name><affiliation wicri:level="3"><nlm:affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name><affiliation wicri:level="3"><nlm:affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany. hemmer@tum.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Crohn Disease (chemically induced)</term><term>Crohn Disease (epidemiology)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multiple Sclerosis (chemically induced)</term><term>Multiple Sclerosis (epidemiology)</term><term>Psoriasis (chemically induced)</term><term>Psoriasis (epidemiology)</term><term>Risk Factors (MeSH)</term><term>Time Factors (MeSH)</term><term>Vaccination (adverse effects)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Maladie de Crohn (induit chimiquement)</term><term>Maladie de Crohn (épidémiologie)</term><term>Mâle (MeSH)</term><term>Psoriasis (induit chimiquement)</term><term>Psoriasis (épidémiologie)</term><term>Sclérose en plaques (induit chimiquement)</term><term>Sclérose en plaques (épidémiologie)</term><term>Vaccination (effets indésirables)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Crohn Disease</term><term>Multiple Sclerosis</term><term>Psoriasis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Crohn Disease</term><term>Multiple Sclerosis</term><term>Psoriasis</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Maladie de Crohn</term><term>Psoriasis</term><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Maladie de Crohn</term><term>Psoriasis</term><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Using the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005-2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or psoriasis (n = 112,292) and participants with no history of these autoimmune diseases (n = 79,185) served as controls.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The odds of MS were lower in participants with a recorded vaccination (odds ratio [OR] 0.870, </p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Results of the present study do not reveal vaccination to be a risk factor for MS. On the contrary, they consistently suggest that vaccination is associated with a lower likelihood of being diagnosed with MS within the next 5 years. Whether this is a protective effect needs to be addressed by future studies.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31363057</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>93</Volume><Issue>9</Issue><PubDate><Year>2019</Year><Month>08</Month><Day>27</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>A large case-control study on vaccination as risk factor for multiple sclerosis.</ArticleTitle><Pagination><MedlinePgn>e908-e916</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000008012</ELocationID><Abstract><AbstractText Label="OBJECTIVE">To investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study.</AbstractText><AbstractText Label="METHODS">Using the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005-2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or psoriasis (n = 112,292) and participants with no history of these autoimmune diseases (n = 79,185) served as controls.</AbstractText><AbstractText Label="RESULTS">The odds of MS were lower in participants with a recorded vaccination (odds ratio [OR] 0.870, <i>p</i> < 0.001 vs participants without autoimmune disease; OR 0.919, <i>p</i> < 0.001 vs participants with Crohn disease; OR 0.973, <i>p</i> = 0.177 vs participants with psoriasis). Lower odds were most pronounced for vaccinations against influenza and tick-borne encephalitis. These effects were consistently observed for different time frames, control cohorts, and definitions of the MS cohort. Effect sizes increased toward the time of first diagnosis.</AbstractText><AbstractText Label="CONCLUSIONS">Results of the present study do not reveal vaccination to be a risk factor for MS. On the contrary, they consistently suggest that vaccination is associated with a lower likelihood of being diagnosed with MS within the next 5 years. Whether this is a protective effect needs to be addressed by future studies.</AbstractText><CopyrightInformation>© 2019 American Academy of Neurology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hapfelmeier</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-6765-6352</Identifier><AffiliationInfo><Affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasperi</LastName><ForeName>Christiane</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donnachie</LastName><ForeName>Ewan</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hemmer</LastName><ForeName>Bernhard</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0001-5985-6784</Identifier><AffiliationInfo><Affiliation>From the Institute of Medical Informatics, Statistics and Epidemiology (A.H.), and Department of Neurology, Klinikum rechts der Isar (C.G., B.H.), Technical University of Munich; National Association of Statutory Health Insurance Physicians of Bavaria (E.D.); and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany. hemmer@tum.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Neurology. 2019 Aug 27;93(9):377-378</RefSource><PMID Version="1">31363059</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003424" MajorTopicYN="N">Crohn Disease</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011565" MajorTopicYN="N">Psoriasis</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31363057</ArticleId><ArticleId IdType="pii">WNL.0000000000008012</ArticleId><ArticleId IdType="doi">10.1212/WNL.0000000000008012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Hapfelmeier, Alexander" sort="Hapfelmeier, Alexander" uniqKey="Hapfelmeier A" first="Alexander" last="Hapfelmeier">Alexander Hapfelmeier</name></region><name sortKey="Donnachie, Ewan" sort="Donnachie, Ewan" uniqKey="Donnachie E" first="Ewan" last="Donnachie">Ewan Donnachie</name><name sortKey="Gasperi, Christiane" sort="Gasperi, Christiane" uniqKey="Gasperi C" first="Christiane" last="Gasperi">Christiane Gasperi</name><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31363057" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV4
| This area was generated with Dilib version V0.6.35. |  |